: any of a breed of tall massive powerful smooth-coated dogs
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The arrangement appeared to be working out well until that morning, when less than an hour after Loyalty's arrival, Miller called 911 to report that the boy had been mauled by her two Great Dane/Mastiff mixes.—Chris Spargo, PEOPLE, 27 Apr. 2026 Spreading joy with Wally, his boxer, Great Dane, hound mix, or his grand-dog, Aja — who are both certified therapy dogs — Derene visits schools, active living communities and other locations.—Lesly Gregory, AJC.com, 18 Mar. 2026 The Great Dane puppy at the center of the mystery is, of course, Scooby-Doo himself.—Hanna Wickes, Charlotte Observer, 24 Feb. 2026 However, a Great Dane–Poodle mix like Oakley is still relatively rare, but doodle-type dogs overall are increasingly showing up in shelters.—Lucy Notarantonio, MSNBC Newsweek, 9 Dec. 2025 See All Example Sentences for Great Dane